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New clinical tools for diagnosing gastric dysfunction

49 months
Approved budget:
Professor Leo Cheng
Health issue:
Proposal type:
Lay summary
Organised contractions of the stomach are essential for digesting food. These contractions are controlled by an underlying electrical activity termed ""slow waves"". Deranged slow wave activity is widely considered to contribute to common and significant diseases such as chronic indigestion and gastric reflux. However, the clinical significance of slow wave disorders remains poorly understood because there are no clinical devices that can accurately assess them. We have assembled an expert multidisciplinary team to develop and apply a new generation of medical devices, in order to critically advance the clinical understanding and therapy of slow wave dysfunction. We will build the new hardware and software in our labs, and then rigorously validate the devices in animal models of health and disease. These devices are non- or minimally invasive and their subsequent translation to clinical use is readily anticipated, with potential to dramatically advance the clinical understanding and treatment of major gastric diseases.