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Mechanisms of gastric dysmotility: advances from cell to clinic

48 months
Approved budget:
Professor Leo Cheng
Health issue:
Proposal type:
Lay summary
Like in the heart, an underlying electrical activity termed the 'slow wave' regulates stomach contractions. Stomach wave dysrhythmias (abnormalities in the slow wave) have been associated with common and significant diseases such as functional dyspepsia and gastroparesis. Post-operative complications have also been attributed to disruption to the normal slow wave conduction due to surgical removal of the natural slow wave pacemaker region of the stomach. We have assembled an international, interdisciplinary team to develop and apply a range of new generation slow wave recording methods, in order to critically advance the fundamental understanding and therapy of gastric dysrhythmias. We will develop new innovative slow wave recording capabilities across multiple platforms and integrate them with advanced signal processing tools that will allow accurate identification of gastric dysrhythmias. These methods will offer high-fidelity and/or minimally-invasive slow wave recordings for translation to improve diagnosis and therapy of these diseases.