Long-term neurological conditions result in great personal, whanau/family and societal burdens that evidence tells us can be reduced with good quality care and support. However, outcomes remain poor for many. Our mixed methods study seeks to address this in a multi-phased and participatory designed quality improvement project. We will develop, integrate into practice and evaluate a Living Well Toolkit to facilitate two-way knowledge exchange between patients and those involved in their care/support. We will work with a range of knowledge users including patients, whanau/family, health and social care professionals, the voluntary sector and funders. Our approach should result in service improvement during the time of the project and develops capacity for participatory research and action in chronic conditions in the future. The Toolkit will embed evidence into practice for assessment and treatment processes, to enhance quality care health and well-being for people with long-term conditions in New Zealand and internationally.