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Cellular mechanisms underlying food allergen sensitisation

Year:
2011
Duration:
36 months
Approved budget:
$1,186,852.42
Researchers:
Professor Graham Le Gros
Health issue:
Inflammatory and immune system
Proposal type:
Project
Lay summary
Food-induced allergic reactions can range from mild discomfort to serious and life threatening events, with anaphylaxis the most severe form of food allergy. The prevalence of allergy and food allergies in particular, continues to increase unabated throughout the world and despite extensive research into the potential epidemiological, genetic or clinical associations of established allergic disease there has been little progress. The major impediment to improving outcomes is the lack of detailed knowledge of the initial cellular and molecular events involved in allergic sensitisation in the gastrointestinal tract. This study aims to develop a novel food allergy susceptible/Th2 cytokine transgene reporter model and use it to reveal for the first time the earliest cellular and molecular events involved in allergic sensitisation in the gastrointestinal tract. This research will address an important gap in food allergy research and inform those involved in developing public health, pharmaceutical and clinical interventions.