2014 Funding Round – Feasibility Study

Professor Richard Beasley
Medical Research Institute of New Zealand
Venous thromboembolism prevention in lower leg injury requiring immobilisation
12 months

Lay summary

Little robust evidence exists for appropriate venous thromboembolism prophylaxis following lower leg injury that requires cast immobilisation. We propose a randomised controlled trial to compare low dose aspirin, an intermittent pneumatic compression (IPC) device to fit under the cast plus aspirin, or a new oral anticoagulant (rivaroxaban) alone. A feasibility trial is required to assess whether this study can be carried out in a single centre and if the IPC device is an acceptable option in this setting.

A total of 70 patients aged 18 to 70 years, presenting to Wellington Hospital and requiring a non weight bearing cast for a lower limb injury will be asked to trial an IPC device for the duration of their non weight-bearing period. They will also be given aspirin. Data will be gathered about device usage, comfort and any side effects relating to its use.

Back to Funding Recipients