e-ASIA Joint Research Program

Professor Gregory Cook
University of Otago
Funder(s): HRC
Whole-genome sequencing of drug-resistant Mycobacterium tuberculosis strains for diagnostics and outbreak detection
36 months

Lay summary

We will determine the role of whole-genome sequencing (WGS) for drug susceptibility testing (DST) of Mycobactrium tuberculosis (TB) in Myanmar and Indonesia, two high TB burden countries. We will investigate discrepancies between genotypic and phenotypic DST results and use WGS to investigate the population structure of resistant M. tuberculosis. We will use WGS to study the transmissibility of drug-resistant strains.

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