2014 Funding Round – Project

Professor Frank Bloomfield
The University of Auckland
ProViDe RCT: Does better early nutrition in preterm babies improve development?
60 months

Lay summary

Providing adequate nutritional intakes, especially of protein, in extremely low birthweight (ELBW, birthweight < 1,000 g) infants in early life is extremely challenging.  Consequently, the majority of ELBW babies have faltering postnatal growth.  Poor growth in ELBW babies is associated with adverse neurodevelopmental outcomes.  We propose a randomised, double-blind, placebo-controlled multi-centre trial of a simple, inexpensive and practical intervention to determine whether, in ELBW babies, an extra 1 g/day of intravenous protein in the first five days after birth will improve survival free from neurodisability at 2 years' corrected age. 

This trial will provide the first evidence on the long-term outcomes of increased protein intake in ELBW babies in early life.  If the intervention is effective, it could be introduced immediately into neonatal units at very little cost with health benefits for these highly vulnerable babies and, therefore, economic benefits for New Zealand.

Back to Funding Recipients