Emerging researcher first grant (2017 funding round)

Dr Michael Collins
Auckland District Health Board
The BEST-fluids study: Better evidence for selecting transplant fluids
48 months

Lay summary

End-stage kidney disease (ESKD) is a significant, expensive health problem in New Zealand and worldwide. Kidney transplantation improves survival, quality of life, and is much cheaper than dialysis treatment. However sometimes kidney transplants function poorly after surgery, and a period of continued dialysis is needed. In addition to complicating recovery, this can adversely affect long-term kidney transplant function and the health of the recipient. Intravenous fluids given during and after transplantation (usually sodium chloride, or saline) are critical to ensure optimal kidney transplant function, but there is evidence that saline may not be the safest fluid to use due to its high chloride content.
The BEST-Fluids study (Better Evidence for Selecting Transplant Fluids) is a clinical trial in kidney transplantation to compare saline with a balanced low-chloride solution, Plasmalyte. The trial will determine whether using Plasmalyte rather than saline will improve kidney transplant function, reduce complications and improve long-term outcomes.

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