Dr Logan Walker
University of Otago, Christchurch
Genetic modifiers of risk of familial breast and ovarian cancer
36 months

Lay summary

The recent development of new gene screening technologies has revolutionised genetic testing of high-risk breast and ovarian cancer patients. Genetic information from these technologies is vital for directing clinical care of patients and their families and has significant implications for disease prevention. Approximately 1/250 individuals inherit a genetic mutation in the genes BRCA1 or BRCA2, which means they are at high-risk of developing breast and ovarian cancer. However, the risk of cancer for these individuals varies significantly due to other (unknown) genetic changes, creating a significant challenge for counselling and clinical decision making. Our proposal aims to exploit a large international collaboration to identify and functionally characterise genetic changes which modify the risk of breast and ovarian cancer in women who have inherited a BRCA1/BRCA2 mutation. Discoveries from this unique proposal will facilitate accurate clinical decision making, and provide new insights into the aetiology of breast and ovarian tumour development.

Back to Funding Recipients