2016 funding round - Emerging Researcher First Grant

Dr Ivanhoe Leung
University of Auckland
Lost in translation: Translation dysregulation and Parkinson's disease
$120,000
36 months

Lay summary

The objective of our project is to understand the causes of Parkinson’s disease from molecular, biochemical and structural perspectives. We aim to achieve our goal by studying how a mutant enzyme called LRRK2, which can be found in up to ~40 per cent of Parkinson’s cases in some ethnic groups, changes the structure, dynamics and function of its substrate, which is a ribosomal protein called s15 that is involved in the assembly of ribosome in translation and protein synthesis.

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