Feasibility Study Grant (2017)

Associate Professor Jeremy Krebs
University of Otago, Wellington
Preventing progression from pre-diabetes to type 2 diabetes in New Zealanders
12 months

Lay summary

Why do Pacific, NZ Māori and South Asian peoples have similarly high rates of obesity and Type 2 diabetes (T2DM) – significantly higher than European New Zealanders - despite having very different body composition? Weight loss through diet and increasing lean mass through resistance training both improve glucose metabolism, but it is unknown whether people with different lean:fat (L:F) mass ratios respond in the same way to these interventions.

This research aims to explore whether there are fundamental physiological differences between people with different L:F mass ratios at high risk of T2DM and whether they respond differently to interventions proven to reduce T2DM which specifically target either weight loss or increasing lean mass. We propose a feasibility study to identify recruitment strategies and barriers to recruitment for the main study; assess the tolerability of baseline investigations, and assess the tolerability and barriers to completion of the proposed dietary and exercise.

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